16S rRNA Methyltransferases: An Emerging Resistance Mechanism Against Aminoglycosides in Salmonella

Infections with non-typhoidal Salmonella are the second most common cause of bacterial gastroenteritis in developed countries, with the incidence of multidrug-resistant non-typhoidal Salmonella increasing considerably in the last two decades. Non-typhoidal salmonellosis in otherwise healthy individuals usually results in mild, self-limiting diarrhoea, but treatment with an appropriate antimicrobial can be life-saving in vulnerable patient groups such as the elderly, immunocompromised patients or those with underlying disease, and in cases of invasive disease such as Salmonella bacteraemia, osteomyelitis and meningitis.